"Building Stronger Bones: The Dynamic Trio of D3, K2, and Borax"
Based on the information from the systematic reviews found through PubMed, vitamin C appears to play a significant role in bone health, particularly in the synthesis of collagen, which is crucial for bone growth and repair. Preclinical studies have demonstrated that vitamin C can accelerate bone formation due to enhanced osteoblastic proliferation and differentiation and its antioxidant function. These effects are particularly noted when pro-oxidant substances are present. While vitamin C supplementation seems to aid in bone regeneration without adverse events in animal studies, the evidence from human studies is not as clear-cut. There is variability in the results regarding its efficacy in human bone healing, and thus, there's no specific recommendation on the dose or route of administration of vitamin C to improve bone healing processes in humans at this time.
The Linus Pauling Institute at Oregon State University also highlights that vitamin C is a necessary cofactor in the enzymatic reactions involved in the synthesis of collagen, which makes up 90% of the bone matrix. Deficiency in vitamin C can impair collagen synthesis and osteoblast adhesion to the bone matrix, which are critical steps in maintaining healthy bones.
In summary, while vitamin C has been shown to have positive effects on bone healing and collagen synthesis in preclinical studies, more human studies are needed to fully understand its role and to establish specific guidelines for supplementation in the context of bone healing and health.
For more detailed information, you can review the studies and their findings through the links provided by PubMed and the Linus Pauling Institute: